Intraductal Papillary Mucinous Neoplasm (IPMN)

Intraductal Papillary Mucinous Neoplasm of Pancreas is a pancreatic tumor that typically arises from the pancreatic duct.

Intraductal Papillary Mucinous Neoplasm (IPMN) of Pancreas is an exocrine, cystic tumor that grows within the pancreatic duct. IPMN cells are characterized by the secretion of mucus, and are typically located in the head region of the pancreas . Disease are more prevalent in elderly adults, typically over the age of 60 years. Although both genders may be affected, these tumor types are frequently diagnosed in men

Intraductal Papillary Mucinous Neoplasms of Pancreas can also be classified on the extent of dysplasia. Dysplasia refers to abnormal growth that results in loss of normal cell and tissue organization

  • Low-grade dysplasia
  • Moderate- or intermediate- grade dysplasia
  • High-grade dysplasia

What are the Risk Factors for Intraductal Papillary Mucinous Neoplasm of Pancreas?

The risk factors for developing Intraductal Papillary Mucinous Neoplasm of Pancreas include:

  • Smoking
  • Exposure to toxic chemicals
  • Family history: Individuals, with one or more (immediate) family members or relatives with a history of pancreatic ductal adenocarcinoma, may have an increased risk of the condition

The following are some signs and symptoms associated with IPMN of Pancreas:

  • Anorexia (loss of appetite)
  • Jaundice, manifested as yellowing of the skin and white part of the eyes
  • Dark urine, also a sign of jaundice
  • Pain in the upper part of the abdomen or middle of the back
  • Fluid accumulation in the abdomen (ascites), abdominal swelling
  • Persistent feeling of abdominal bloating with nausea or vomiting
  • Feeling full soon after eating less (having a feeling of satiety after eating less)
  • Changes in bowel movements, such as constipation
  • Fatty stools
  • The formation of blood clots in veins, swelling of legs
  • Frequent urination (polyuria), excessive thirst, and blurred vision - all signs of elevated blood sugar levels in the body
  • Fatigue, feeling tired easily
  • Unintended weight loss
  • Depression

HOW IS INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM OF PANCREAS TREATED?

The treatment options for Intraductal Papillary Mucinous Neoplasm of Pancreas may vary, depending on the location of the cystic lesion, the grade of IPMN, and whether there is an invasive component to the lesion. For those with asymptomatic or low-grade IPMN of Pancreas and no associated risk factors, treatment may not be necessary, other than regularly monitoring the condition with periodic imaging of the organ.

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